Orbitrap Excedion Pro Mass Spectrometer

Elevate your biopharma characterization:

• Detect low abundant Asp/IsoAsp isomerization
• Detailed structural elucidation: Discern Leucin and Isoleucin isobaric masses with great confidence
• Top-up the sequence coverage in middle-down analysis with fast radical driven fragmentation

Innovate higher-order structure characterization of biomolecules:

• ETD fragmentation option enables near single residue resolution in bottom-up and top-down Hydrogen-Deuterium Exchange (HDX) analysis with high sensitivity for alternative fragmentation ETD in ion routing multipole and combination of EThcD in the ion routing multipole for detection in the Orbitrap mass analyzer
• Fast and sensitive ETD reaction of precursor ion with fluoranthene radical anions (m/z 202) injection into the IRM to generate a series of c/z-fragment ions. EThcD fragmentation enabled by reaccelerating ETD fragment ions into IRM for HCD fragmentation
• HDX based MS offers a comprehensive and novel toolset for the analysis of protein conformation, conformation dynamics, and protein-protein interactions

Exceed in proteomics research:

• Accurate quantification with extended dynamic range
• Hybrid-DIA
• Deep proteome coverage
• PTMs analysis with ETD fragmentation
• Immunopeptidomics with EThCD fragmentation

Discovery in metabolomics research:

• Increased sensitivity up to 10x compound dependent
• Enhanced Dynamic Range (eDR)
• Increased unknown annotations

Detection Limits:

• Full Scan: < 1.5 fg reserpine on column
• MS2: < 1.5 fg reserpine on column
• SIM: < 0.8 fg reserpine on column

Simultaneously measure multiple parameters within a single experiment:

Up to 20 precursor ions per scan