The Orbitrap Astral Mass Spectrometer combines three mass analyzers: a quadrupole mass analyzer for high selectivity and high ion transmission, an Orbitrap mass analyzer for high dynamic range and high resolution measurements, and the novel Astral analyzer for fast and sensitive measurements. By combining these three mass analyzers and orchestrating the coordination of 5 separate ion packets within the instrument in parallel a new standard for mass spectrometry performance is achieved to unlock new insights into biology and disease mechanisms.
יצרן: Thermo Fisher Scientific
The Orbitrap Astral Mass Spectrometer enables the analysis of 180 samples in a single day at a depth of over 8,000 protein groups per sample. That's over 1.4 million protein group data points measured in a single day, achieved with a high throughput injection-to-injection cycle of just 8 minutes.
The Orbitrap Astral Mass Spectrometer provides a depth of 12,000 proteins in 1 hour with a single shot or over 15,000 proteins in 4.5 hours with multiple shots using bottom-up proteomics to measure human cell lysates. The near whole-proteome coverage of these methods reduces the chances of missing out on important proteins of interest.
The complex heterogeneity of biology necessitates measurements of limited cell populations or single cells. The high dynamic range of the proteome requires measurements of very low copy number proteins. The Orbitrap Astral Mass Spectrometer can identify over 5,000 proteins from a single–cell equivalent input and accurately quantifies proteins with just a few hundred copies in bulk samples.
Biological changes are quantitative in nature, requiring accurate and precise measurements to determine statistically significant biomarkers. The Orbitrap Astral Mass Spectrometer extends the dynamic range of accurate quantitative measurements at a faster throughput and with deeper coverage.
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